ABSTRACT:Background: Diabetes Mellitus (DM) is an “iceberg” disease seen in all age groups. India shall have the largest number of diabetics by 2030. Type 2 DM is a metabolic disorder with inappropriate hyperglycemia either due to an absolute or relative deficiency of insulin secretion or reduction in the biologic effectiveness of insulin (Insulin resistance – IR) or both. IR is genetically programmed and is influenced by a combination of environmental and physical factors like diet and obesity. IR could increase risk for the early onset of DM in children of diabetics.Methods: The body mass index (BMI), waist circumference (WC), blood pressure (BP), fasting plasma glucose (FPG), fasting plasma insulin (FPI), HOMA-IR (Homeostatic model assessment – IR) parameters were measured and statistically compared in 30 nondiabetics with family history of type 2 DM and 30 age matched nondiabetics without family history of type 2 DM.Results: The FPI (8.79 ± 3.06) and HOMA-IR (1.94 ± 0.86) were statistically significant (p<0.05) in the FH + group when compared to the FH – group. WC and BP showed a trend towards increase in the FH + group.Conclusion: There is hyperinsulinemia and IR in the FH + group. The complex genetic predisposition to IR and its association with the increasing WC in the FH + group predisposes such individuals to the development of type 2 DM.
Archive for October, 2012
ABSTRACT:-Cancer is an ageold disease which has claimed millions of human lives along with other fatal diseases . Cancer of the cervix is the most prevalent form of cancer in developing countries especially the South -East Asia region The present study is undertaken to determine the efficacy of the crystallisation test for the detection of malignancy in cancer cases of the female genital tract and also to determine the efficacy of this test to detect the precancerous conditions ( Erosion of cervix etc.) of the female genital tract and to know whether the results of crystallisation test correlate with the histopathological diagnosis of cancer and precancerous cases. Crystallisation test was carried out in 300 female patients from Gynaecology wards of Government Medical College and Hospital, Aurangabad.Out of 300 cases studied ,211 cases were diagnosed cancer patients , 39 cases were in precancerous stage and 50 were non-cancer cases.The non-cancer cases, including 10 normal cases were taken as a control.Out of 211 diagnosed cancer cases,92 were histologicaly proved cancer case. Positive results were obtained in 94.7% cases of malignancy.Positive results were obtained into 84.6% of precancerous cases. To all the cancer and non-cancer cases of the female genital tract,Chi-Square test was applied,degree of freedom was calculated and the significance of the test i.e. P value was calculated.P value was found to be far less than 0.001 .This indicates that the crystallization test is statistically highly significant test for the detection of malignancy.